脏活检发现的频谱与甲基胺使用相关
Hae Yoon Grace Choung1, Cynthia C Nast1, Mark Haas1
1Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA.
Kidney international reports
|July 31, 2024
概括
甲基胺 (METH) 的滥用与严重的损伤有关,包括急性管状缩和血球硬化. 在METH使用者中早期发现功能障碍和蛋白尿对于控制这些毒性影响至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
- 药物滥用研究 药物滥用研究
背景情况:
- 甲基胺 (METH) 是一种被广泛滥用的非法药物,其毒作用报告不足.
- 关于与METH使用相关的损伤和组织病理变化谱的数据有限.
研究的目的:
- 调查有史以来METH滥用病例的患者的毒效应和组织病理学发现.
- 描述METH使用者的脏活检发现,区分单纯METH和多物质使用者.
主要方法:
- 对112名有METH滥用病史的患者进行了回顾性分析.
- 分类为仅使用METH (62名患者) 和METH加其他药物 (60名患者) 的队列.
- 对脏活检结果和临床数据的审查.
主要成果:
- 97%的METH使用者表现出功能障碍;65%的人患有蛋白尿. 常见的诊断包括急性管管 necrosis (ATN,66%) 和焦点细分质硬化症 (FSGS,53%).
- 管介质性炎 (TIN),血栓性微血管病变 (TMA) 和糖尿病样硬化症 (DG) 也很普遍.
- 肌红蛋白ATN与同时滥用乙醇有关 (P=0.002),仅使用METH的用户显示了更高的DG率 (P=0.01).
结论:
- 甲使用与广泛的病理有关,经常呈现为急性损伤 (AKI) 和蛋白尿.
- 组织病理学发现强调了METH的显著毒性潜力,需要临床意识和进一步研究.
关键词:
急性功能衰竭急性功能衰竭慢性脏疾病 慢性脏疾病滥用药物滥用药物滥用药物滥用药物滥用药物滥用药物甲基胺的使用方法公共卫生公共卫生.拉布多米溶解 (rhabdomyolysis) 是一种治疗方法.更多相关视频
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