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内皮功能障碍生物标志物和CKD发生率在REGARDS队列中
Samuel A P Short1, Katherine Wilkinson2, D Leann Long3
1Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Kidney international reports
|July 31, 2024
概括
内皮功能障碍生物标志物,包括细胞间细胞粘附分子1 (ICAM-1),血管细胞粘附分子1 (VCAM-1),第八因子 (FVIII) 和E-selectin,与慢性病 (CKD) 和功能下降的风险增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管科学 心血管科学
- 生物标志物研究 生物标志物研究
背景情况:
- 慢性病 (CKD) 具有超出传统风险因素的多因素原因.
- 内皮功能障碍是CKD中已知的并发症,也是其发展的潜在贡献者.
研究的目的:
- 调查内皮功能障碍的循环生物标志物与CKD发生率之间的关联.
- 探索这些生物标志物与功能下降和白蛋白尿症之间的关系.
主要方法:
- 利用来自"因地理和种族差异导致中风的原因" (REGARDS) 研究的数据,对30239名成年人的前性队列进行了研究.
- 测量ICAM-1,VCAM-1,FVIII和E-selectin的基线水平在3300名没有流行CKD或albuminuria的参与者中.
- 在9.4年的随访期内使用后勤回归模型评估事件CKD,eGFR下降和事件albuminuria.
主要成果:
- 较高度的ICAM-1,VCAM-1,FVIII和E-selectin与发生的CKD有显著的关联 (ORs在1.10至1.15之间).
- 这些生物标志物还与估计的膜过率 (eGFR) 降低≥30%有关.
- 升高的FVIII水平与发生性白蛋白尿特别相关,而其他生物标志物则没有.
结论:
- 内皮功能障碍的循环生物标志物 (ICAM-1,VCAM-1,FVIII,E-selectin) 与患CKD的风险增加和经历严重功能下降有关.
- 除了与整体CKD发病率的关联之外,VIII因子可能在白蛋白尿的发展中发挥特定的作用.
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