婴儿的肠道微生物组:为肥胖的早期发病奠定了基础
Yvonne Vallès1, Muhammad Arshad2, Mamoun Abdalbaqi1
1Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Frontiers in microbiology
|July 31, 2024
概括
孕前母亲的肥胖可能会影响婴儿的肠道微生物组合,可能会导致肥胖的发展. 早期的肠道细菌在肥胖母亲产生的婴儿中表现出特定的变化,这表明早期的肥胖性微生物群的发展.
科学领域:
- 微生物组研究的研究.
- 儿科卫生健康 儿科卫生健康
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 全球肥胖率的上升与生活方式和遗传学有关.
- 慢性炎症和代谢疾病风险的特征是肥胖.
- 肠道微生物组越来越被认为是肥胖发展的一个因素.
研究的目的:
- 调查与母亲怀孕前体重相关的早期婴儿肠道微生物组.
- 确定母亲的肥胖与肥胖的婴儿微生物组是否相关.
- 确定与孕产妇肥胖状况相关的特定微生物种群和功能.
主要方法:
- 婴儿便样本的枪支测序 (生命的第一年).
- 从肥胖和正常体重的母亲的婴儿 (每人n=23) 的样本分析.
- 对微生物群多样性,种群和功能途径的统计分析.
主要成果:
- 婴儿微生物组多样性受到时间的影响,而不是母亲怀孕前的状态.
- 在6个月的肥胖母亲的婴儿中观察到更高的Bacillota/Bacteroidota比率 (p=0.02).
- 在6个月起的肥胖母亲的婴儿中*Akkermansia municiphila*和*Faecalibacterium prausnitzii*的消耗 (p<0.01).
- 在肥胖母亲的婴儿1周 (p=0.02) 中,丁相关途径的丰富 (UDP-N-乙-D-葡萄糖胺生物合成II).
结论:
- 母亲怀孕前的肥胖可能会在生命早期微妙地影响婴儿肠道微生物组合.
- 特定的微生物和功能变化表明,肥胖原生微生物群的发展可能是早期机制.
- 需要进一步的研究来确认因果关系和对预防肥胖的影响.
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