在高度敏感的脏移植接受者接受脱敏疗法时,解变化改变了全反应性记忆B细胞
Johan Noble1,2,3, Lara Cabezas1,2, Aurelie Truffot3,4
1Nephrology, Hemodialysis Apheresis and Kidney Transplantation, Department, CHU Grenoble Alpes, Grenoble, France.
概括
即使在无敏化后,抗捐赠者B细胞也会在接受移植的接受者中持续存在. 向B细胞糖解可能提供一种新的治疗策略,以防止抗体介导排斥.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
- 细胞的新陈代谢
背景情况:
- 接受移植的超免疫患者面临抗体中介排斥的高风险.
- 脱敏感化策略旨在减少捐赠者特异性抗体 (DSA),但抗捐赠者B细胞可以持续存在.
研究的目的:
- 为了研究抗捐赠者B细胞在高度敏感的移植接受者中对抗捐赠者B细胞的持续性和代谢变化.
- 评估向B细胞代谢以防止排斥的潜力.
主要方法:
- 这项研究包括10名高度敏感的接受者,在移植之前接受了脱敏化 (血分泌,B细胞枯竭).
- 量化DSA,B细胞子集,抗捐赠HLAB细胞和单细胞代谢通过Luminex,流细胞计和光点测定.
- 序列样本采集在脱敏前,移植时和移植后6-12个月.
主要成果:
- 脱敏感化减少了DSA和总记忆/天真B细胞,但血细胞和记忆抗捐赠者B细胞持续长达12个月.
- 移植后,记忆B细胞显示葡萄糖分解增加,而血细胞将新陈代谢从葡萄糖依赖转移.
- 持久的抗捐赠者B细胞表现出改变的代谢特征,包括增加的糖分分解能力.
结论:
- 抗捐赠者B细胞在移植接受者中存在,尽管有效地减少了DSA.
- 这些持久性B细胞的代谢适应性,特别是它们对糖解的依赖,表明它们是潜在的治疗点.
- 向B细胞糖解可能是一个新的策略,以改善高度敏感的移植受体的结果.
更多相关视频
相关概念视频
01:40Cell-mediated Immune Responses
68.0K
Overview
68.0K
01:23Cells of the Adaptive Immune Response
972
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
972
01:24B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
01:20Special Features of Adaptive Immunity
785
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
785