CurQfen®-curcumin对认知障碍的影响:一个随机,双盲,安慰剂控制,三臂,三序相对比的研究
S Syam Das1, Prasad M Gopal2,3, Jestin V Thomas4
1Akay Natural Ingredients, Kochi, Kerala, India.
Frontiers in dementia
|July 31, 2024
概括
高度生物可用CurQfen-curcumin (CGM) 改善了阿尔茨海默病患者的认知和运动功能. 这种黄素配方为延缓痴呆症进展提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 黄素的生物可用性差,限制了它对神经退行性疾病的有效性.
- 黄素可以穿越血脑屏障,并与粉样质斑块和团交互.
研究的目的:
- 评估高生物可用CurQfen-curcumin (CGM) 在改善阿尔茨海默病患者痴呆症的疗效.
- 评估CGM对认知和运动功能以及关键生物化学标记物的影响.
主要方法:
- 一项为期6个月的双盲,安慰剂控制的研究,涉及48名中度阿尔茨海默病患者.
- 参与者接受了安慰剂,标准黄素或CGM (每天两次400毫克).
- 认知 (MMSE) 和运动器官 (GLFS) 功能,以及血清生物标志物 (BDNF,Aβ42,tau,IL-6,TNF-α) 进行了比较.
主要成果:
- 与安慰剂和标准黄素相比,CGM补充剂显著改善了MMSE和GLFS得分.
- 血清中BDNF,Aβ42,陶蛋白,IL-6和TNF-α的水平在CGM组显著改善.
- 集团内部和集团间的分析证实了这些显著的改善 (P < 0.05).
结论:
- 补充CurQfen-curcumin (CGM) 显著延迟了阿尔茨海默病的进展.
- 在痴呆症患者中,CGM改善了认知和运动器官功能.
- CGM证明了治疗神经退行性疾病 (如阿尔茨海默氏症) 的治疗潜力.
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