在更年期过渡期间的认知轨迹
Stephanie Than1,2,3, Chris Moran1,2,3,4, Richard Beare1,3,5
1Academic Unit, Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Frontiers in dementia
|July 31, 2024
概括
绝经期间的认知能力下降有所不同. 与更年期前妇女相比,更年期后妇女的反应时间下降速度最慢,这表明心理运动速度对更年期过渡敏感.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 妇女健康 妇女健康
背景情况:
- 女性性别与更高的痴呆症患病率有关.
- 更年期可能会影响认知差异和痴呆风险.
- 了解更年期过渡期间的认知变化至关重要.
研究的目的:
- 为了调查认知衰退率是否在更年期的不同阶段有所不同.
- 分析更年期对各种认知功能的影响.
主要方法:
- 来自英国生物库的15486名女性被按更年期状态分层 (更年期前,更年期前,更年期后).
- 纵向认知功能 (反应时间,推理,记忆,注意力) 被评估了8年.
- 模型根据年龄,教育,种族,APOEε4,更年期荷尔蒙疗法 (MHT) 和大脑MRI体积进行了调整.
主要成果:
- 更年期状态和时间之间的相互作用影响了反应时间 (p < 0.01).
- 与绝经前妇女相比,绝经后妇女的反应时间增长 (恶化) 最慢 (β = -1.07,p = 0.02).
- 绝经前和绝经后的女性显示整体流体智力和记忆力较差,但与绝经前妇女相比,变化率相似.
结论:
- 绝经前期和绝经后期与认知变化有关.
- 心理运动速度对更年期过渡特别敏感.
- 需要使用先进的神经成像进行进一步的研究,以了解神经基础.
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