久坐不动的行为,来自大脑的神经营养因子和中年大脑结构:对年轻成年人冠状动脉风险发展的纵向脑MRI子研究
Xuan Zhang1, Osorio D Meirelles1, Zhiguang Li1
1Laboratory of Epidemiology and Population Sciences Intramural Research Program, National Institute on Aging, Baltimore, MD, United States.
Frontiers in dementia
|July 31, 2024
概括
较高的大脑衍生神经营养因子 (BDNF) 水平可能会保护大脑免受长时间久坐的负面影响. 这一发现表明,BDNF可以缓冲与不活动相关的大脑体积减少的情况.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 公共卫生 公共卫生
背景情况:
- 大脑衍生神经营养因子 (BDNF) 与身体活动和认知功能有关.
- 久坐不动的时间与认知能力下降有关.
- 久坐不动行为,大脑健康和BDNF之间的关系尚未完全理解.
研究的目的:
- 调查BDNF是否调解或缓解了中年成人中久坐时间和MRI估计的大脑体积之间的关联.
- 检查横截面和纵向关联.
主要方法:
- 利用了年轻成年人冠状动脉风险发展脑MRI子研究 (n=612基线,n=418随访) 的数据.
- 通过MRI评估静坐时间,大脑总量,白质,灰质和海马体积.
- 采用一般线性回归模型来分析BDNF的调节和调节效应,对共变量进行调整.
主要成果:
- 较长的久坐时间与较低的总大脑,灰质和海马体积的横截面相关.
- BDNF并没有调解静坐时间和大脑体积之间的关联.
- BDNF调节了这种关联,较高的BDNF水平减少了久坐时间对总和白质大脑体积的负面影响.
- 从长度上看,较高的基线BDNF与较少的脑容量下降有关,独立于久坐时间.
结论:
- 较高的BDNF水平可能会对久坐不动行为对大脑结构的有害影响产生保护作用.
- BDNF的调节作用表明,一种潜在的机制可以在久坐不动的人中保持大脑体积.
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