影响COVID-19相关肺部阿斯伯吉洛症死亡率的因素:国际ID-IRI研究
Meyha Sahin1, Mesut Yilmaz1, Ali Mert1
1Istanbul Medipol University, Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
接受皮质类固醇治疗的COVID-19相关性肺炎 (CAPA) 的老年患者面临更高的死亡风险. 这种风险被诸如晚年和器官支持,特别是多器官衰竭等因素所放大.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 在重症监护机构中,COVID-19相关的肺性阿斯伯吉洛症 (CAPA) 构成了重大挑战.
- 在CAPA中确定死亡率预测因子对于改善患者的治疗结果至关重要.
研究的目的:
- 确定影响COVID-19相关肺部阿斯伯吉洛症 (CAPA) 诊断的患者死亡率的因素.
主要方法:
- 一项回顾性横截面研究,涉及来自15个国家的23个中心的162名患者 (2020年3月至2021年12月).
- 利用多变量考克斯回归和决策树分析来确定死亡率预测因素.
- 收集关于患者人口统计,治疗和临床结果的数据.
主要成果:
- 在90天内,在162名患者中的113名患者中观察到死亡率.
- 死亡率的关键预测因素包括65岁以上的年龄,血管压缩剂治疗和CAPA诊断时的置换疗法.
- 接受COVID-19皮质类固醇治疗的65岁以上患者的死亡率较高.
结论:
- 患有CAPA的老年患者,特别是接受皮质类固醇治疗的患者,死亡风险明显增加.
- 多器官衰竭,需要血管压缩剂或替代疗法,进一步增加了这一群体的死亡风险.
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