抵抗训练可以促进胰岛素抵抗小鼠的乳酸运输体和突触蛋白
Xuepeng Bian1,2, Mingming Li2, Shujie Lou2
1Department of Rehabilitation, School of International Medical Technology, Shanghai Sanda University, Shanghai, China.
Heliyon
|July 31, 2024
概括
抵抗训练通过降低乳酸和增强突触可塑性蛋白质来改善胰岛素抵抗中的大脑健康. 这种运动干预增强了海马体中的关键分子通路.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 运动生理学 运动生理学
背景情况:
- 胰岛素抵抗与海马体内突触可塑性受损有关.
- 这种损伤背后的分子机制需要进一步阐明.
研究的目的:
- 研究抵抗训练对胰岛素耐药小鼠突触可塑性蛋白的影响.
- 探索阻力训练诱导的改善所涉及的分子机制.
主要方法:
- 在使用高脂肪饮食的小鼠中,在12周内诱导胰岛素抵抗.
- 鼠标接受了为期12周的爬梯耐力训练计划,或者保持久坐状态.
- 干预后分析了血液和海马组织.
主要成果:
- 抗胰岛素的小鼠表现出血中乳酸的升高,突触可塑性蛋白质的降低以及Akt/mTOR信号的改变.
- 抵抗训练逆转了这些变化,减少了乳酸盐,增加了mTOR,MCT和可塑性蛋白的表达/酸化.
- 细胞转化启动因子4E结合蛋白2的表达在胰岛素抵抗中发生了变化.
结论:
- 抵抗训练可以改善胰岛素抵抗,并增强海马突触可塑性.
- 改善与正常化的乳酸水平和增强的mTOR/MCT信号通路有关.
- 需要进一步的研究来证实PI3K/Akt路径激活和乳酸利用的作用.
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