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在固体器官移植接受者中感染了斯特朗基洛伊德菌 (Strongyloides stercoralis)

John I Hogan¹, Sapna A Mehta^2,3

¹NYU Grossman Long Island School of Medicine.

Current opinion in infectious diseases

|July 31, 2024

概括

斯特朗基洛伊德 (Strongyloides stercoralis) 感染对实体器官移植接受者 (SOTR) 构成风险. 优化查,治疗和供体查可以减少SOTR.的并发症.

科学领域:

传染性疾病传染性疾病
移植医学移植医学
公共卫生公共卫生

背景情况:

斯特朗基洛伊德 (Strongyloides stercoralis) 感染是固体器官移植接受者 (SOTR) 的一个重大问题.
它可能导致高发病率,并构成由供体衍生的感染 (DDI) 的风险.
有效的管理对于预防移植后并发症至关重要.

研究的目的:

审查Strongyloides stercoralis感染的主要流行病学方面.
在器官移植候选人中为慢性感染的查和治疗策略提供信息.
在移植后的环境中减少感染并发症.

主要方法:

综述目前关于Strongyloides stercoralis流行病学和管理的文献.
在SOTR.中对查和治疗的建议进行分析.
包括来自器官采购和移植网络的更新的捐赠者查指南.

主要成果:

关于斯特朗基洛伊德高感染综合征和传播感染的最佳管理指南.
关于治疗后监测和可能在免疫抑制下重复治疗的建议.
更新了对已故和活体器官捐献者的查建议.

结论:

优化对Strongyloides感染的治疗可以降低SOTR的风险.
在危险时期治疗后的监测是必不可少的.
普遍的捐赠者查政策可以进一步加强降低风险.

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