评估严重急性呼吸道综合征冠状病毒2感染对血液学参数的影响
Badi A Alotaibi1,2, Jehad A Aldali3, Hamzah J Aldali4
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
概括
在COVID-19患者的血细胞计数和凝血因子的变化可能表明疾病的严重程度. 这项研究分析了2019年新冠肺炎 (COVID-19) 患者的这些参数,以预测死亡风险.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 临床病理学 临床病理学
背景情况:
- COVID-19 (冠状病毒疾病2019) 呈现出各种不同的临床表现.
- 在COVID-19患者中经常观察到血液和凝血异常.
- 预测疾病严重程度和死亡率仍然是一个关键的挑战.
研究的目的:
- 为了评估成年COVID-19患者全血细胞计 (CBC) 和凝血参数的变化.
- 确定这些血液学变化是否可以预测疾病严重程度和死亡率.
- 调查COVID-19对血液参数影响的潜在性别特异性差异.
主要方法:
- 74,800名成年患者的回顾性分析.
- 分类为四组:COVID-19阳性/阴性和按性别.
- 在COVID-19阳性和阴性组之间的CBC和凝血参数的比较.
主要成果:
- 在COVID-19患者中,白细胞数量下降,红细胞数量增加.
- 在COVID-19阳性个体中观察到延长的部分血栓形成时间和较低的D-二次体水平.
- 确定了对血小板计数的性别相关影响,以及凝血变化与死亡率之间的联系.
结论:
- 血液细胞计数和凝血参数的变化是COVID-19患者死亡的潜在风险因素.
- 血液学标记可能有助于预测2019年冠状病毒疾病的结果.
- 需要进一步的研究来澄清由于人口和时间变化的相互矛盾的证据.
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