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Updated: Jun 25, 2026

Introducing a Gene Knockout Directly Into the Amastigote Stage of Trypanosoma cruzi Using the CRISPR/Cas9 System
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一种使用α-碳酸无水酶的计算方法,以寻找Trypanosoma cruzi抗原剂

Eyra Ortiz-Perez1, Domingo Mendez-Alvarez1, Alfredo Juarez-Saldivar2

  • 1Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, México.

Medicinal chemistry (Shariqah (United Arab Emirates))
|July 31, 2024
PubMed
概括

对查加斯病的新药发现至关重要,因为目前的治疗方法是无效的. 这项研究确定了来自硫胺衍生物的强有力的碳酸酶抑制剂,具有针对Trypanosoma cruzi的有前途的tripanocidal活性.

关键词:
试osoma cruzi 是一种类型的虫.碳酸无水酶是一种碳酸.查加斯病是查加斯病的一种疾病.分子对接的分子对接.硫胺酸硫胺的使用方法虚拟查. 虚拟的查.

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American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...