在肝细胞癌中,SIRT4与微血管透,免疫细胞透和上皮细胞介质过渡有关
Juan Li1, Ming Zhao2, Weiwei Fan3,4
1Department of Pathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Histology and histopathology
|July 31, 2024
概括
在具有微血管透 (MVI) 的肝细胞癌 (HCC) 中,SIRT4表达减少,与EMT和免疫细胞相关联. SIRT4不是HCC的独立预后标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 了解与HCC进展相关的分子标志物对于开发向疗法至关重要.
研究的目的:
- 为了评估HCC标本中的SIRT4表达.
- 研究SIRT4水平,临床病理因素和微血管透 (MVI) 之间的关系.
- 探索SIRT4在HCC进展中的作用,包括其与上皮-介质细胞过渡 (EMT) 和免疫细胞透的关联.
主要方法:
- 免疫组织化学染色被用来评估108个HCC标本中的SIRT4表达.
- 微血管透 (MVI) 被分为M0,M1和M2亚型.
- 进行了生物信息学分析,以确定SIRT4的生物功能和预后价值.
主要成果:
- 与正常组织相比,HCC组织中的SIRT4表达率更高.
- 在M1/M2 MVI的HCC中,SIRT4水平显著降低 (p=0.003).
- SIRT4表达与EMT标记物,CD4+T/NK细胞和下调的癌症相关纤维细胞相关,但不是整体临床结果.
结论:
- 在HCC进展中,SIRT4表达与MVI,免疫细胞透和EMT有关.
- SIRT4不是HCC的独立预后标志物.
- 需要进一步研究SIRT4在HCC发病过程中的作用.
更多相关视频
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.1K
08:40A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
Published on: August 7, 2020
6.2K
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K