COVID-19对发作和患者患者行为的影响
Gönül Akdağ1, Niyazi Uysal1, Mustafa Çetiner1
1Kutahya Health Sciences University, Faculty of Medicine, Department of Neurology, Kutahya, Turkey.
概括
随着COVID-19大流行,发作频率在15%的患者中增加. 使用多种抗发作药物的多疗法被确定为在此期间增加发作的重要危险因素.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- COVID-19大流行对全球健康产生了深远的长期影响.
- 患有 (PWE) 的人可能特别容易受到与大流行有关的干扰.
- 了解流行病对管理和结果的影响至关重要.
研究的目的:
- 评估COVID-19大流行对PWE中发作频率的长期影响.
- 为了评估疫情期间PWE中精神困境的水平.
- 识别与发作频率增加相关的风险因素.
主要方法:
- 2021年5月,在土耳其进行了一项横截面研究.
- 通过电话收集的数据包括综合征,抗发作药物,发作频率和医疗记录中的耐药性.
- 凯斯勒心理痛苦度量10 (K-10) 和一个定制问卷评估了人口统计,临床特征和与大流行有关的变化.
主要成果:
- 在227名PWE中,81.9%的人报告了显著的精神困扰 (K-10分数≥30).
- 在15%的患者中,发作的频率增加.
- 在单变量分析中,犹寻求紧急护理是高风险因素 (OR=8.325),而在多变量分析中,多疗法是唯一重要的因素 (OR=2.945).
结论:
- 一年后的流行病声明,增加的压力和增加的发作频率在PWE中持续存在.
- 多疗法成为增加发作频率的主要预测因素.
- 这些发现凸显了在公共卫生危机期间对PWE的持续监测和支持的需要.
相关概念视频
Antiepileptic Drugs: Potassium Channel Activators
157
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
157
Arteries of the Lower Limbs
182
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
182
Seizures: Classification
317
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
317
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
279
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
279
Antiepileptic Drugs: Sodium Channel Blockers
475
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
475
Antiepileptic Drugs: GABAergic Pathway Potentiators
363
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
363


