基于16srRNA基因测序技术的多发性硬化症患者肠道微生物群的变化:一篇综述和元分析
Xiaoyun Zhang1, Zhiqiang Wei2, Zhen Liu3
1Department of Rehabilitation, Shenzhen Longhua District Central Hospital, 518000 Shenzhen, Guangdong, China.
Journal of integrative neuroscience
|July 31, 2024
概括
在多发性硬化症 (MS) 中,肠道微生物群的多样性可能会在活跃的疾病阶段和复发性缓解性MS (RRMS) 中减少. 微生物组成的变化,而不仅仅是多样性,是理解多发性硬化机制的关键.
科学领域:
- 微生物组研究的研究.
- 神经免疫学 神经免疫学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 肠道微生物群在多发性硬化症发病过程中的作用正在调查中.
- 16S核糖体RNA (rRNA) 基因测序是微生物组分析的一个关键工具.
研究的目的:
- 分析多发性硬化症 (MS) 患者肠道微生物群的变化.
- 研究肠道微生物多样性与MS特征之间的关系.
- 探索微生物组成与多发性硬化症疾病机制之间的潜在联系.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括在便样本上使用16S rRNA基因测序的观察性研究.
- 使用纽卡斯尔-太华尺度对所包含研究的质量评估.
主要成果:
- 分析了2015年至2022年的26项研究 (2885名参与者).
- 在MS患者和对照人群之间,阿尔法多样性没有总体显著差异.
- 在活跃的MS阶段和复发性复发性MS (RRMS) 现型中观察到微生物多样性的减少.
- 在促炎性细菌体或抗炎性固体中没有一致的变化.
结论:
- 在MS中肠道微生物组的改变是复杂的,其组成可能比多样性更重要.
- 疾病活动和表型对MS的肠道微生物群有适度的影响.
- 需要进一步的纵向研究来澄清肠道微生物群,MS进展和治疗之间的相互作用.
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