在囊性纤维化中肺移植的结果
Nicholas Avdimiretz1, Kieran Halloran2, Christian Benden3,4
1Division of Pediatric Pulmonary, Asthma, and Sleep Medicine, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California, USA.
Current opinion in pulmonary medicine
|July 31, 2024
概括
肺移植 (LTX) 为晚期囊性纤维化肺病 (ACFLD) 患有囊性纤维化肺病 (pwCF) 的人提供了很好的生存率. 然而,CFTR调节器疗法正在减少pwCF中对LTX的需求.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 医学遗传学 医学遗传学
背景情况:
- 肺移植 (LTX) 是晚期囊性纤维化肺病 (ACFLD) 的关键干预措施.
- 对于ACFLD来说,LTX已成为所有年龄组的公认治疗方法.
- 本综述侧重于LTX作为囊性纤维化 (CF) 的治疗方法.
研究的目的:
- 审查囊性纤维化作为LTX的首要指示.
- 要突出LTX结果,包括CF患者的存活率和继发症.
- 检查随着时间的推移对CF的LTX的不断变化的格局.
主要方法:
- 目前关于LTX治疗囊性纤维化病的文献的综述.
- 对生存数据和移植后结果的分析.
- 讨论影响结果和并发症的因素.
主要成果:
- 对于患有CF (pwCF) 的人来说,LTX显示出优异的长期存活率,随着时间的推移显著改善.
- 专门的CF护理中心和共同疾病的认可有助于更好的结果.
- 地区之间存在结果差距 (例如,加拿大与加拿大相比). 美国) 和青少年.
- CFTR调节器治疗导致CF的LTX下降,长期影响不确定.
结论:
- 对于ACFLD来说,LTX仍然是一个可行的和被接受的选择,改善了生活质量和生存率.
- 当与患者的护理目标保持一致时,它是一种至关重要的治疗方法.
- CFTR调节器的出现正在重塑LTX在CF管理中的作用.
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