多种造血源的巨体存在于正在发育的前列腺中
Sally W Feng1,2, Tanya M North1,2, Peri Wivell1,2
1Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Development (Cambridge, England)
|July 31, 2024
概括
前列腺巨细胞对于器官发育至关重要,不由雄激素直接调节. 这些来自胚胎和骨髓来源的免疫细胞影响前列腺神经发育.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 组织寄居的巨细胞对于器官生成至关重要.
- 前列腺的生长依赖于雄激素,但雄激素通常具有免疫抑制作用.
- 人们对前列腺巨细胞在发育中的作用知之甚少.
研究的目的:
- 在产后发育期间对前列腺巨细胞进行表征.
- 调查它们的局部化,雄激素受体 (AR) 表达和起源.
- 评估巨细胞剥离对前列腺器官生成的影响.
主要方法:
- 发展中的小鼠前列腺中髓状细胞种群的表征.
- 在前列腺巨细胞中核雌激素受体表达的评估.
- 使用血统追踪和骨髓模拟器对巨细胞起源的分析.
- 在产后前列腺发育期间,巨细胞的过渡性切除.
主要成果:
- 骨髓状细胞,包括巨细胞 (Cx3cr1+),在青春期前列腺中非常丰富.
- 大多数前列腺巨细胞不表达核受体.
- 前列腺巨细胞表现出双重起源:胚胎衍生组织居民和成人骨髓衍生.
- 巨细胞与前列腺神经纤维有关,这表明它们在神经模式中的作用.
结论:
- 前列腺巨细胞存在于青春期,并不是由雄激素直接准.
- 它们代表了一种混合的组织居民和招募细胞的种群.
- 这些巨细胞在前列腺神经模式中发挥作用.
- 研究结果提供了关于先天性免疫在前列腺健康和疾病 (包括癌症) 中的作用的见解.
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