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在Ehrlich的实验性瘤小鼠模型中,Ocimum basilicum L. (大) 呈现出亲亡的活性

Phelipe Gabriel Dos Santos Sant'Ana¹, William Gustavo Lima², Gabriela Francine Martins Lopes¹

¹Universidade Federal de São João del-Rei - Departamento de Medicina - Laboratório de Patologia Experimental - Divinópolis (MG) - Brazil.

Acta cirurgica brasileira

|July 31, 2024

概括

乙醇提取物Ocimum basilicum L. (EEOb) 降低了埃里希克.

科学领域:

药理学和毒理学药理学和毒理学
癌症研究癌症研究
自然产品化学自然产品化学

背景情况:

自然产品是潜在治疗剂的丰富来源.
奥西 (Ocimum basilicum L.) (大) 具有各种已记录的药用特性.
埃里希实验性瘤 (EET) 是评估抗癌药物的广泛使用的模型.

研究的目的:

为了研究Ocimum basilicum L. (EEOb) 乙醇提取物的抗瘤功效.
在小鼠模型中评估EEOb对埃里希实验性瘤 (EET) 的治疗效果.

主要方法:

瑞士小鼠被接种了埃里希的实验性瘤 (EET) 细胞.
通过在28天内测量脚厚度来评估瘤的生长.
组织病理学分析包括AgNOR染色和PCNA,Bcl-2和Bax的免疫组织化学.

主要成果:

给予EEOb (100 mg/kg) 显著降低了埃里希的固体瘤生长.
在接受治疗的瘤中观察到基核组织区域 (AgNORs) 的减少.
EEOb治疗导致Bcl-2表达的减少,这表明诱导了亡.

结论:

每日服用EEOb对埃里希实验性瘤具有显著的抗瘤活性.
作用机制涉及诱导瘤细胞中的亡.
在癌症治疗中,Ocimum basilicum L. 提取物显示出作为治疗剂的潜力.

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