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Updated: Jun 18, 2025

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增强器驱动的基因调控网络从单细胞RNA-seq和ATAC-seq数据推断

Yang Li1, Anjun Ma1,2, Yizhong Wang3

  • 1Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, United States.

Briefings in bioinformatics
|July 31, 2024
PubMed
概括

这项研究引入了STREAM,一种从单细胞数据推断基因调节网络的新方法. STREAM准确地识别了转录因子-增强剂-基因关系,进步了我们对基因调节的理解.

关键词:
施泰纳森林问题模型生物网络是一个生物网络.数据集成数据集成数据集成这就是 scATAC-seqq.这就是scRNA-seqq.亚模块化优化的优化

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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