内在能力及其生物学基础:一个范围审查
M B Beyene1, R Visvanathan, A T Amare
1Azmeraw T. Amare, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia, Tel: +61 8 83137438,
The Journal of frailty & aging
|July 31, 2024
概括
由内在能力 (IC) 定义的健康衰老与各种健康因素有关. 需要进一步研究基因和环境对IC的影响,利用生物库数据.
科学领域:
- 老年学与公共卫生
- 遗传学和衰老研究研究
背景情况:
- 世界卫生组织 (WHO) 在2015年推出了内在能力 (IC),作为基于功能能力的健康衰老的衡量标准.
- 本范围审查审查审查了IC指数得分的开发,验证和关联,以及其生物基础.
研究的目的:
- 总结关于内在能力 (IC) 开发和验证的证据.
- 探索IC与健康相关因素之间的关联.
- 确定IC的遗传机制和基因与环境相互作用的研究缺口.
主要方法:
- 在六个主要的科学数据库中进行了全面的文献搜索.
- 与内在能力 (IC) 相关的关键词被用于确定相关研究.
主要成果:
- 包括84篇文章,其中38篇使用5个领域的IC运营方法.
- 内在能力与社会人口因素,生活方式,功能状态和健康结果有显著的关联.
- 虽然复合IC生物基础研究是有限的,但特定的IC域表明了实质性的遗传性 (20-85%) 和已识别的遗传变异,但基因与环境相互作用数据不存在.
结论:
- 发现了不一致的标准化IC测量工具,但IC指数表现出良好的构造和预测有效性.
- 在理解影响IC的遗传和基因与环境相互作用方面存在重大差距.
- 建议利用大型生物库数据集来对IC的遗传基础进行未来的研究.
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