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Philip J Richards¹, Abeer Almutrafy¹, Lu Liang¹

¹Division of Microbiology, Brewing and Biotechnology, School of Biosciences, University of Nottingham, Loughborough, Leicestershire, United Kingdom.

|July 31, 2024

概括

饮食中摄入的银酸 (GOS) 增强肉对沙门氏菌 (Salmonella Enteritidis) 的肠道殖民抵抗力. GOS补充剂通过增加有益的肠道细菌和短链脂肪酸 (如酸盐) 来加速沙门氏菌的清除.

科学领域:

禽畜科学禽畜科学禽畜科学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

* *肉中的沙门氏菌污染构成公共卫生风险.
* *通过卫生或疫苗接种来根除沙门氏菌并非具有成本效益.
* 增强肠道微生物群的殖民抵抗力是一个有前途的补充方法.

研究的目的:

* 确定参与肉中的沙门氏菌*殖民抗性的细菌种群.
* 调查 prebiot galactooligosaccharides (GOS) 在促进殖民抗性的作用.
* 为了确定GOS介导的 * 沙门氏菌 * 清除是否与先天性免疫反应或短链脂肪酸 (SCFA) 生产有关.

主要方法:

* 肉被以小麦和大豆为基础的饮食,有或没有GOS,持续24天.
* 在20天后,被口服挑战了Salmonella enterica* 血清 Enteritidis.
分析了沙门氏菌的殖民,肠道微生物群的组成,免疫反应和脏SCFA度.

主要成果:

*饮食GOS显著缩短了清除*S*的时间. 来自Ceca. 的Enteritidis.
* *沙门氏菌*的挑战与一种Acidaminococcaceae细菌分类的丰富性增加有关.
*GOS补充剂导致propionate和valerate的Cecal度显著更高,与Acidaminococcaceae分类与积极相关.
*没有观察到显著的亲炎性转录反应,这表明清除不是免疫介导的.

结论:

* 益生菌GOS增强了肉中对沙门氏菌的殖民抵抗力.
* GOS促进了有益细菌的生长,如Acidaminococcaceae,这些细菌产生酸盐和酸盐.
*增加的SCFA水平,特别是酸,可能有助于快速清除沙门氏菌,而不会引起炎症.

关键词:

这就是GOS.这就是SCFAFA.沙门氏菌是一种沙门氏菌.这些都是肉肉.银河系酸和酸.微生物组是一个微生物组.我们的微生物群.益生菌益生菌前生物酸 propionate 的使用方法值得一提的是,它是值得的.

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