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Updated: Jun 18, 2025

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
07:18

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

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ORC1增强了HIV-1 LTR上的压制性表观遗传修饰,以促进HIV-1潜伏性

Mo Zhou1,2, Tao Yang1, Ming Yuan1

  • 1Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.

Journal of virology
|July 31, 2024
PubMed
概括

科学家们发现,起源识别综合体1 (ORC1) 通过招募压制性表观遗传因素来维持人类免疫缺陷病毒1型 (HIV-1) 延迟. 削弱ORC1会重新激活潜伏的HIV-1,为HIV-1治愈提供了一个新的治疗点.

关键词:
艾滋病毒-1潜伏期这就是LLPS.与LTR相关的因素在 ORC1 中,ORC1 是 ORC1 的前身.压制性的表观遗传修饰.

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