脂肪细胞和免疫细胞之间的细胞细胞交叉
Jiadai Liu1,2, Yong Chen1,2,3
1Department of Endocrinology, Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
概括
免疫细胞调节热生脂肪组织,对能量平衡和肥胖治疗至关重要. 了解这种免疫脂肪细胞交叉交谈为代谢障碍提供了新的治疗策略.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 脂肪组织生物学 脂肪组织生物学
- 能量的恒常状态 (Energy homeostasis) 是一种能量的恒常状态.
背景情况:
- 肥胖是一种全球代谢障碍,药物选择有限.
- 热生脂肪组织 (棕色和色) 是肥胖治疗的关键目标.
- 免疫细胞对脂肪细胞功能的调节,特别是热生成,尚未完全理解.
研究的目的:
- 审查热生成脂肪细胞和免疫细胞之间的相互作用.
- 阐明脂肪组织中免疫代谢的细胞和分子机制.
- 为了突出肥胖的潜在治疗点.
主要方法:
- 文献综述侧重于免疫细胞-脂肪细胞相互作用.
- 对细胞因子信号传递,神经免疫调节和线粒体转移的分析.
- 综合关于脂肪组织免疫代谢的当前知识.
主要成果:
- 免疫细胞显著影响热源性脂肪细胞的发育和功能.
- 细胞因子,特别是介质蛋白,在调节发热过程中起着至关重要的作用.
- 神经免疫通路和线粒体转移代表了热量产生中的新机制.
结论:
- 免疫细胞和脂肪细胞之间的交叉对脂肪组织平衡和全身能量平衡至关重要.
- 准脂肪组织的免疫微环境可以提高发热效率.
- 了解免疫代谢提供了新的肥胖干预措施的基础.
相关概念视频
01:40Cell-mediated Immune Responses
68.0K
Overview
68.0K
01:23Cells of the Adaptive Immune Response
972
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
972
01:38Inflammation
53.3K
Overview
53.3K
01:24T Cell Types and Functions
967
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
967