在接受嵌合抗原受体T细胞治疗的患者中,甲素水平值和抗生素的使用
Murari Ramesh1, Alex Yartsev1,2
1Intensive Care Unit, Westmead Hospital, Sydney, Australia.
Hematology (Amsterdam, Netherlands)
|July 31, 2024
概括
甲素 (PCT) 可以帮助识别接受仿制抗原受体 (CAR) T 细胞治疗的患者的败血症. 低于0.5μg/L的PCT水平可能有助于排除败血症,而1.5μg/L的门则有助于诊断.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 化学抗原受体 (CAR) T细胞治疗患者容易感染和败血症.
- 这些患者的细胞因子释放综合征 (CRS) 可以模仿败血症.
- 目前正在研究普罗卡尔西托尼 (PCT) 作为该群体感染的生物标志物.
研究的目的:
- 确定用于在接受CAR T细胞治疗的患者中诊断感染的特定普卡尔西托尼 (PCT) 值.
- 在接受CAR T细胞治疗的患者中,区分感染与细胞因子释放综合征 (CRS).
主要方法:
- 每天PCT水平被测量为14天后的CAR T细胞输注或直到医院出院.
- 在感染和没有感染的患者之间比较PCT值.
- 分析了16名患者的初步数据.
主要成果:
- 只有12.5%的患者发生了感染.
- 败血症患者的PCT水平升高,在第七天达到2.6μg/L,而未感染的患者保持在0.5μg/L以下.
- 观察到一种朝着早期和自由的抗生素管理的趋势.
结论:
- 在CAR T细胞治疗患者中,PCT是风险分层和诊断感染并发症的宝贵工具.
- 建议PCT值为1.5μg/L用于诊断败血症.
- 一个PCT值<0.5μg/L可能有助于排除败血症,当白细胞计数和CRP由于CRS或淋巴细胞减少而不可靠时.
关键词:
化学抗原受体治疗 化学抗原受体治疗抗微生物药物管理管理c反应性蛋白质是什么细胞因子释放综合征 细胞因子释放综合征感染的感染感染.炎症反应是一种炎症反应.这是什么意思? procalcitonin.这是一种血症.更多相关视频
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