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结肠癌的紧急切除对长期瘤结果具有独立和不利的影响

Marta Sandini¹, Stefania Piccioni¹, Simona Badalucco¹

¹Department of Medicine, Surgery and Neurosciences, Unit of General Surgery and Surgical Oncology, University of Siena, Strada delle Scotte, 4, Siena, 53100, Italy.

Journal of gastrointestinal cancer

|July 31, 2024

概括

与选择性手术相比,紧急结肠直肠癌 (CRC) 手术与更高的术后并发症和更差的长期存活率有关. 这凸显了及时干预的重要性,以改善CRC管理中的患者结果.

科学领域:

在瘤学瘤学.
外科胃肠道外科手术
临床结果研究研究

背景情况:

紧急与选择性结肠直肠癌 (CRC) 切除的结果正在讨论中.
这项研究评估了紧急与可选CRC手术的短期和长期结果.

研究的目的:

为了比较紧急和选择性结直肠癌 (CRC) 切除术之间的短期术后发病率和长期存活率.
确定在接受手术的CRC患者中生存的独立预测因素.

主要方法:

对225名为CRC进行结肠切除的患者进行了回顾性队列研究 (2013-2017年).
术后并发症,手术切除标准和使用卡普兰-梅尔曲线和考克斯比例危险模型的长期存活率的比较.

主要成果:

紧急CRC手术患者年龄较大,并具有较高的并发症评分 (ASA,CCI).
紧急手术显示,严重并发症的发生率显著上升,道泄漏,重新手术和术后死亡率显著上升.
紧急病例的整体存活率明显较差 (中位数为41个月,而未达到),紧急手术是低生存率的独立预测因素.

结论:

紧急结肠直肠癌 (CRC) 切除导致术后发病率和死亡率增加.
尽管瘤切除标准相似,但紧急手术独立预测CRC患者的整体存活率更差.

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