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基线F-FDG PET/CT放射学用于扩散性大B细胞淋巴瘤的预后预测,具有外节涉

Fenglian Jing¹, Xinchao Zhang², Yunuan Liu¹

¹Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, Hebei, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|July 31, 2024

概括

基线18F-FDGPET/CT放射学可以预测扩散大B细胞淋巴瘤 (DLBCL) 预后,在患者与外节干涉 (ENI). 结合临床数据,PET参数和放射学数据的综合模型显示,预测无进展和整体存活率的准确性更高.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

扩散性大B细胞淋巴瘤 (DLBCL) 与外节参与 (ENI) 呈现出一个复杂的预后挑战.
准确的预后对于定制DLBCL患者的治疗策略至关重要.

研究的目的:

评估基线18F-FDG PET/CT放射学对ENI患者DLBCL预后的预测能力.
开发和验证一个结合放射学,临床变量和传统PET参数的预后模型.

主要方法:

分析了一组126名患有ENI的DLBCL患者.
最小绝对收缩和选择运算符 (LASSO) 考克斯回归从1328个初始特征中确定了最佳的放射性特征.
结合放射性评分,临床变量和传统PET参数的组合模型被开发出来,以预测无进展生存 (PFS) 和整体生存 (OS).

主要成果:

综合模型显示,与单独的放射学或单独的临床变量相比,PFS和OS的预测性能优越,由较低的Akaike信息标准 (AIC) 值表明.
与其他模型相比,组合模型在PFS (0.724) 和OS (0.842) 中实现了较高的一致性指数 (C指数).
卡普兰-梅尔分析显示,高风险组的复发和死亡率明显高于低风险组 (P <0.05).

结论:

基线18F-FDGPET/CT放射学对预测ENI患者DLBCL预后具有显著的潜力.
结合临床数据,传统PET参数和放射学特征的综合预后模型为患者分层和结果预测提供了更高的准确性.

关键词:

扩散大的B细胞淋巴瘤.涉及到外部的参与.聚乙烯/聚乙烯/聚乙烯预测预后预测预测无线电学 (Radiomics) 是一种放射学.

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