压力,大脑下垂体-垂体-上腺轴,大脑下垂体-垂体-上腺轴,以及攻击性
Ngala Elvis Mbiydzenyuy1,2, Lihle-Appiah Qulu3
1Basic Science Department, School of Medicine, Copperbelt University, P.O Box 71191, Ndola, Zambia.
Metabolic brain disease
|July 31, 2024
概括
本综述探讨了下丘脑-垂体-上腺 (HPA) 和下丘脑-垂体-腺 (HPG) 轴如何影响侵略. 了解这些荷尔蒙相互作用,包括皮质醇和,是开发侵略性相关疾病治疗的关键.
科学领域:
- 神经内分泌学神经内分泌学
- 行为神经科学 行为神经科学
- 激素研究 研究 激素研究
背景情况:
- 侵略是一种由多个生物系统影响的复杂行为.
- 下垂体-垂体-上腺 (HPA) 轴和下垂体-垂体-上腺 (HPG) 轴是关键的神经内分泌系统,参与压力和生殖.
- 这些轴的失调与各种行为障碍有关,包括侵略性.
研究的目的:
- 提供HPA轴,HPG轴和攻击性行为之间的相互作用的全面审查.
- 阐明攻击背后的生理和神经生物学机制.
- 探索对临床干预和未来研究方向的影响.
主要方法:
- 文献综述综合了动物和人类研究的发现.
- 分析葡萄糖皮质激素 (如皮质醇) 和雄激素 (如) 在侵略中的作用.
- 检查HPA和HPG轴之间的反机制和交叉声.
主要成果:
- 通过皮质醇的HPA轴和通过的HPG轴显著调节侵略性行为.
- 慢性压力可以调节HPA轴,影响皮质醇水平,并可能增加侵略性.
- 在水平和侵略之间存在积极的关联,通过神经回路中的雄激素受体进行介导.
结论:
- HPA和HPG轴之间的复杂相互作用是侵略的神经生物学的核心.
- 了解这些荷尔蒙和神经通路对于开发针对性治疗策略来治疗与侵略有关的疾病至关重要.
- 整合分子,细胞和电路层面的方法,以及翻译性研究,将推动我们对侵略的理解和治疗.
更多相关视频
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
3.0K
09:12The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
Published on: July 4, 2013
70.8K
相关概念视频
Hypothalamic-Pituitary Axis
59.8K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.8K
Physiological Foundation of Stress
56
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
56
Introduction to Stress and Lifestyle
99
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
99
The Sympathetic Nervous System
94.7K
Overview
94.7K
Aggression
27.8K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
27.8K
Hormones of the Adrenal Glands
2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K
