使用离子液体催化剂进行功能化烯酸酸盐的合成,抗微生物和对接研究
Sowjanya Bandlapalli1, Reddi Mohan Naidu Kalla2, Venkata Narayana Palakollu1
1Department of Chemistry, School of Applied Sciences, REVA Univeristy, Banglore, 560064, India.
Molecular diversity
|July 31, 2024
概括
这项研究提出了一种具有成本效益的方法,用于利用胆氧化物合成功能化烯酸酸盐. 合成的化合物显示出有前途的抗菌和抗真菌活性,通过分子对接研究确定.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 绿色化学 绿色化学
背景情况:
- 功能化基酸酸盐是有价值的含化合物.
- 有效且具有成本效益的合成方法对于它们的应用至关重要.
- 离子液体在有机合成中具有作为催化剂的潜力.
研究的目的:
- 开发一种简单,高产和环保的协议,用于合成功能化基酸.
- 评估合成的化合物及其抗微生物潜力.
- 通过分子对接研究来研究作用机制.
主要方法:
- 一合成包括2-基甲,二乙和基酸盐.
- 在室温清洁条件下使用胆氧化离子液的催化.
- 抗微生物活性查和分子对接对抗DNA Gyrase B和Aspergillus niger内葡萄糖酶.
主要成果:
- 在没有净化步骤的情况下,高产量的功能化基酸盐的成功合成.
- 胆氧化物被证明是一种有效且廉价的催化剂.
- 化合物4a,4d,4l,4p和4q对微生物点表现出显著的结合亲和力 (-6.9到-7.4千卡/mol).
结论:
- 开发的协议提供了一条有效和可持续的途径,以功能化基酸盐.
- 合成的化合物具有显著的抗菌和抗真菌特性.
- 特定的化合物显示出作为微生物感染的治疗剂的潜力.
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