粘膜和外壁治疗以及克罗恩病的长期结果
Bruce E Sands1, Silvio Danese2,3, J Casey Chapman4
1The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Inflammatory bowel diseases
|July 31, 2024
概括
在克罗恩氏病中,粘膜愈合 (MH) 和外腔愈合 (TH) 与更好的长期患者结局有关. 标准化对MH和TH的评估对于改善克罗恩病管理至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
背景情况:
- 克罗恩氏病的治愈评估是复杂的,临床症状往往与疾病状态不一致.
- 粘膜愈合 (MH) 和外腔愈合 (TH) 是关键指标,但定义和长期结果相关性需要澄清.
研究的目的:
- 系统地审查有关在克罗恩氏病中测量粘膜愈合 (MH) 和超神经愈合 (TH) 的文献.
- 检查MH和TH与临床,经济和生活质量结果的关联.
主要方法:
- 进行了系统的文献审查,搜索数据库查找2012年至2022年的研究.
- 包括现实世界的证据和干预性研究,报告了成年克罗恩病患者的MH或TH关联.
主要成果:
- 分析了46项研究 (5530名患者). 在39项研究中报告了MH结果,在13项研究中报告了TH结果.
- 获得MH或TH的患者通常表现出改善的临床结果,减少医疗保健利用率 (少入院/手术),以及更高的缓解率,特别是在TH.
结论:
- 粘膜和外腔治愈与成年克罗恩病患者的长期积极结果相关.
- 建议对评估MH和TH采取标准化措施和更少的侵入性工具,以优化患者监测和护理.
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