TGF-β

Sajjad Aftabi1,2,3, Amir Barzegar Behrooz1,4, Marco Cordani5,6

  • 1Department of Human Anatomy and Cell Science, University of Manitoba College of Medicine, Winnipeg, Canada.

The FEBS journal
|July 31, 2024
PubMed
概括

转化生长因子-β (TGF-β) 最初抑制肺部瘤,但后来通过增强转移和免疫逃避,促进晚期癌症. 对TGF-β信号的进一步研究对于开发向性肺癌疗法至关重要.

相关概念视频

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K