在平均风险个体中,基于便的结直肠病变检测的诊断性能:现实世界的证据研究
Catherine Cheney1, Alice Parish2, Donna Niedzwiecki2
1Department of Medicine, Duke University Medical Center.
多目标便DNA (mt-sDNA) 和便免疫化学测试显示出类似的结直肠癌查性能. 然而,mt-sDNA测试可以检测到更先进的状病变,从而改善早期检测.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 结肠直肠癌 (CRC) 查对于早期检测和改善结果至关重要.
- 基于便的测试 (SBT) 为CRC查提供了一个非侵入性的选择.
- 不同SBT的现实性能数据对于临床决策至关重要.
研究的目的:
- 评估和比较用于结直肠癌查的不同便测试 (SBT) 的现实性能.
- 通过SBTs评估先进瘤的检测率,包括腺癌,先进腺瘤和先进的状病变.
主要方法:
- 对平均风险个体进行了回顾性审查.
- 在SBTs的积极结果之后进行了结肠镜检查,以确认晚期瘤的存在.
- 性能指标在多目标便DNA (mt-sDNA) 测试和便免疫化学测试 (FIT) 之间进行了比较.
主要成果:
- 在mt-sDNA测试 (30.7%) 和FIT (22.8%) (P = 0.16) 之间的晚期瘤总体检测中没有观察到统计学上显著的差异.
- 在检测高级状病变方面发现了显著差异,mt-sDNA检测了11.3%的FIT,而FIT的1.8% (P<0.001).
结论:
- 在结直肠癌查期间,mt-sDNA和FIT都有效检测晚期瘤.
- 与FIT相比,多目标便DNA测试显示出更高的能力来检测先进的形病变.
- 这些发现凸显了mt-sDNA测试在识别癌前病变的特定子集方面的潜在好处.
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