手术前的氧化丁宁减少了手术后的阿片类药物的使用,这些是儿童常见的泌尿外科手术
Michael Lin-Brande1, Nicholas H Chakiryan1, Aaron P Bayne1
1Department of Urology, Oregon Health & Science University, Portland, Oregon.
The Journal of urology
|July 31, 2024
概括
一次性手术前剂量氧化丁宁显著减少了小儿泌尿病患者的阿片类药物使用. 这种低风险的干预可以减少术后疼痛管理需求.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 尿道排水的泌尿外科手术通常会导致与导管相关的膀不适.
- 这种不适会导致术后发病率增加和依赖阿片类药物.
研究的目的:
- 评估单次手术前剂量氧丁宁能否降低儿科泌尿病患者手术后立即使用阿片类药物的情况.
- 评估氧丁宁在需要内置尿道排水的手术后对疼痛管理的影响.
主要方法:
- 对134名接受尿道外科手术的儿科患者进行了回顾性研究.
- 患者在手术前接受了基于体重的单次口服剂量.
- 主要结局是术后服用阿片类药物;多变量回归分析了相关因素.
主要成果:
- 42名患者接受了氧丁宁,92名患者没有;群体在人口统计和手术因素方面相似.
- 与对照组 (47%) 相比,oxybutynin组的术后阿片类药物使用量减少 (19%).
- 手术前的氧丁宁与接受手术后阿片类药物的风险降低了77% (OR 0.23,P < .001).
结论:
- 一次性手术前剂量氧化丁宁显著降低了儿科患者的术后阿片类药物使用,这些患者内存尿道排水.
- 这种干预风险低,易于实施,用于控制疼痛,减少泌尿外科手术后的阿片类药物依赖.
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