Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Novel DT40 Antibody Library for the Generation of Monoclonal Antibodies.

Virologica Sinica·2019
Same author

Pre-pregnancy maternal fasting plasma glucose levels in relation to time to pregnancy among the couples attempting first pregnancy.

Human reproduction (Oxford, England)·2019
Same author

Fast and accurate decoding of Raman spectra-encoded suspension arrays using deep learning.

The Analyst·2019
Same author

Pharmacokinetic and exposure-response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer.

Cancer chemotherapy and pharmacology·2019
Same author

Identification of diagnostic long non‑coding RNA biomarkers in patients with hepatocellular carcinoma.

Molecular medicine reports·2019
Same author

Ion-chelation based digital barcodes for multiplexing of a suspension array.

The Analyst·2019

相关实验视频

Updated: Jun 27, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

13.9K

早期生物标志物用于预测女性生育能力的等离子体蛋白质学分析:一个嵌套的病例对照研究.

Lingling Huang1, Xiang Hong1, Xuening Zhang2,3,4

  • 1Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.

Journal of proteome research
|July 31, 2024
PubMed
概括

血中高水平的酸盐可能表明女性生育能力增加,这表明它是生育能力的潜在生物标志物. 这一发现可能有助于预测受孕成功率.

关键词:
它们的生育能力和生育能力.女性的血蛋白质是女性的血蛋白质.预测 预测 预测 预测蛋白质组学 蛋白质组学皮鲁酸是一种酸盐.

更多相关视频

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

2.4K
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

358

相关实验视频

Last Updated: Jun 27, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

13.9K
Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

2.4K
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

358

科学领域:

  • 生殖生物学 生殖生物学
  • 生物化学 生化学
  • 临床诊断 临床诊断 临床诊断

背景情况:

  • 女人的生育能力对于生殖成功至关重要.
  • 确定可靠的生育能力生物标志物对于生殖健康至关重要.
  • 目前评估生育能力的方法存在局限性.

研究的目的:

  • 识别和验证用于预测女性生育能力的新型血蛋白标记物.
  • 调查特定代谢物与受孕率之间的关联.

主要方法:

  • 嵌套病例控制研究设计.
  • 蛋白质组学用于生物标志物发现,其次是西式涂抹,ELISA和生物化学测试用于验证.
  • 采用了接收器操作特征 (ROC) 曲线分析和Cox比例危险回归.

主要成果:

  • 酸盐,一种糖溶解产物,在具有高生育能力的妇女中显著增加.
  • ROC分析显示,pyruvate的曲线下面的面积为0.68,表明了预测值.
  • 在pyruvate水平和生育能力之间观察到线性正相关性.

结论:

  • 酸盐作为预测女性生育能力的非侵入性生物标志物具有前景.
  • 较高的酸盐水平与更高的怀孕概率相关.
  • 进一步的研究可以探索pyruvate在生殖健康评估中的作用.