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相关概念视频

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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相关实验视频

Updated: Jun 18, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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通过修改的非怀孕参考间隔来定义妊娠时甲状腺功能障碍:个体参与者的元分析.

Joris A J Osinga1,2, Scott M Nelson3, John P Walsh4,5

  • 1Department of Internal Medicine, Erasmus University Medical Center, 3000 CA Rotterdam, the Netherlands.

The Journal of clinical endocrinology and metabolism
|July 31, 2024
PubMed
概括

对于甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的修改后非怀孕参考间隔没有充分接近孕妇的三个月特定间隔. 需要进一步研究三个月特定间隔的临床意义.

关键词:
怀孕 怀孕 怀孕 怀孕 怀孕参考值是指指标值的参考值.甲状腺功能测试测试甲状腺功能测试甲状腺腺是什么?甲状腺是什么?甲状腺增生蛋白 甲状腺增生蛋白甲状腺素 甲状腺素

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科学领域:

  • 内分泌学 在内分泌学.
  • 生殖医学 生殖医学
  • 临床化学 临床化学

背景情况:

  • 对于妊娠时的甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 建立局部三个月特定的参考间隔是具有挑战性的.
  • 需要使用替代策略来准确评估怀孕期间的甲状腺功能.

研究的目的:

  • 系统地评估TSH和FT4.4的非怀孕参考间隔的标准化修改的诊断性能.
  • 为了将这些修改后的间隔与已确定的三个月特定的参考间隔进行比较.

主要方法:

  • 分析了来自甲状腺和怀孕联盟的前性队列数据.
  • 用绝对,相对 (5%的增量) 和固定极限方法修改了甲状腺参考间隔.
  • 在不同方法中, (亚) 临床甲状腺功能低下的患病率,敏感性和积极预测值 (PPV) 进行了比较.

主要成果:

  • 对于明显的甲状腺功能低下症的最佳修改: -5%的TSH上限, +5%的FT4下限 (灵敏度:0.70,PPV:0.64).
  • 亚临床甲状腺功能低下症的最佳修改: -20%的TSH上限, -15%的FT4下限 (灵敏度:0.91,PPV:0.71).
  • 绝对和固定的修改显示了类似的结果,但宽的置信区间限制了概括性.

结论:

  • 没有对非怀孕期的TSH和FT4参考间隔进行测试的修改. 适当近似的三个月特定间隔.
  • 未来的研究应该专注于三个月特定间隔和基于风险的决策限制的临床相关性.