Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genetic Variation01:25

Genetic Variation

271
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
271
Multiple Allele Traits01:49

Multiple Allele Traits

34.1K
The Concept of Multiple Allelism
34.1K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Infection01:20

Infection

7.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.8K
Genetic Lingo01:11

Genetic Lingo

102.4K
Overview
102.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Polar growth factor PgfA regulates polar peptidoglycan synthesis as well as mycolate synthesis in <i>Mycobacterium smegmatis</i>.

bioRxiv : the preprint server for biology·2026
Same author

An activator of a two-component system controls cell separation and intrinsic drug resistance in <i><i>Mycobacterium tuberculosis</i></i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

An activator of a two-component system controls cell separation and intrinsic drug resistance in <i>Mycobacterium tuberculosis</i>.

bioRxiv : the preprint server for biology·2025
Same author

Evolutionarily divergent Mycobacterium tuberculosis CTP synthase filaments are under selective pressure.

Nature communications·2025
Same author

The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection.

Cell reports·2025
Same author

The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking.

Cell reports·2024

相关实验视频

Updated: Jun 18, 2025

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes
07:44

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Published on: February 14, 2025

799

病原体中的表型异质性

Jessica Sherry1, E Hesper Rego1

  • 1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA; email: jessica.sherry@yale.edu, hesper.rego@yale.edu.

Annual review of genetics
|July 31, 2024
PubMed
概括
此摘要是机器生成的。

病原体种群使用表型异质性,而不仅仅是遗传多样性,以适应宿主. 这种适应性增强了生存能力,并影响了像黄金葡萄球菌 (Staphylococcus aureus) 这样的细菌的感染结果.

关键词:
细菌病原体是一种细菌病原体.主体病原体相互作用现象型异质性的异质性一个单细胞技术的技术.

更多相关视频

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.2K
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

8.8K

相关实验视频

Last Updated: Jun 18, 2025

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes
07:44

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Published on: February 14, 2025

799
A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.2K
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

8.8K

科学领域:

  • 微生物学 微生物学
  • 传染性疾病 传染性疾病
  • 细菌病原体的产生

背景情况:

  • 传统上,病原体多样性是通过遗传异质性来研究的.
  • 遗传多样性有助于治疗逃脱和疾病进展.
  • 新兴研究揭示了基因相同的病原体中的表型异质性.

研究的目的:

  • 审查细菌病原体中表型异质性建立的机制.
  • 探索表型异质性与感染结果之间的联系.
  • 要突出关键的细菌物种:金黄色葡萄球菌,沙门氏菌 typhimurium,Pseudomonas aeruginosa,和结核菌菌.

主要方法:

  • 文献综述侧重于细菌病原体中的表型异质性.
  • 对建立和维持表型变异的研究进行分析.
  • 检查将异质性与感染进展和宿主相互作用联系起来的研究.

主要成果:

  • 现型异质性发生在基因相同的病原体种群中.
  • 这种异质性使病原体能够更好地适应宿主环境.
  • 讨论了建立和维持表型变异的具体机制.

结论:

  • 现型异质性是细菌病原体生存和毒性的关键因素.
  • 了解表型多样性为传染病动态提供了新的见解.
  • 针对表型异质性可能是一个新的治疗策略.