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在各种类型的人类瘤组织中检测和量化微塑料

Jun Zhao¹, Haibo Zhang², Lei Shi²

¹Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China; Reproductive Center, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Ecotoxicology and environmental safety

|July 31, 2024

概括

在人类瘤中发现了微塑料 (MP),可能会改变瘤免疫微环境 (TIME). 胰腺瘤显示免疫细胞减少和中性粒细胞增加,这表明MP可能会对癌症免疫产生负面影响.

科学领域:

环境科学环境科学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

微塑料 (MP) 在人体组织中越来越多地被检测到.
人类瘤和瘤免疫微环境 (TIME) 中MPs的存在和影响仍然基本上是未知的.

研究的目的:

研究MPs在人体瘤中的存在和类型.
探索国会议员对时代的潜在影响,特别是胰腺癌.

主要方法:

分析了61个人类瘤样本,使用热解气体染色学和质谱学.
对MP存在,类型和度的定性和定量评估.

主要成果:

在61个瘤样本中,在肺,胃,结肠直肠,宫和胰腺类型的26个样本中检测到MP.
聚钢,聚乙烯和聚乙烯被确定为MP类型.
有MP的胰腺瘤显示CD8+T细胞,自然杀伤细胞和树突细胞减少,中性粒细胞增加.

结论:

微塑料存在于各种人类瘤中,检测速率和度各不相同.
在胰腺癌中,MPs可能会诱导一种更具免疫抑制性的TIME.
需要进一步的研究来确定MP是否促进瘤进展并影响免疫治疗的疗效.

关键词:

人类人类人类人类人类微塑料是一种微塑料.热解气色谱学质谱学质谱学瘤是一个瘤.瘤的免疫微环境

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