相关实验视频
Updated: Jun 18, 2025

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
暴露于合成类固醇激素和女孩早期青春期:一个病例控制研究
Jingyi Tang1, Yao Chen2, Peng Xue1
1School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China; Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Hainan 572022, China.
对合成类固醇激素的暴露,特别是halcinonide和budesonide,与年轻女孩的早期青春期有关. 该研究表明,环境管理是预防的关键.
科学领域:
- 环境科学 环境科学
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 合成类固醇激素越来越被认为是环境污染物.
- 它们对青春期的时间,尤其是早发性青春期的影响还不太清楚.
- 了解这些关联对于公共卫生和环境政策至关重要.
研究的目的:
- 调查暴露于合成类固醇激素和年轻女孩早期青春期发生之间的关系.
- 为了确定与早期青春期相关的特定激素.
- 为了评估多次合成类固醇激素暴露的综合效应.
主要方法:
- 一项涉及229名年龄在6-9岁的中国女孩的病例控制研究.
- 尿样以超高性能液体染色学-双重质谱法 (UPLC-MS/MS) 分析合成类固醇激素.
- 青春期通过坦纳分期评估;统计分析包括LASSO,逻辑回归,WQS和BKMR模型.
主要成果:
- 个体分析显示,早发性和西诺尼德和布德索尼德暴露之间存在逆相关性.
- 联合效果模型 (WQS和BKMR) 没有发现整体类固醇激素混合物与早熟青春期之间的显著关联.
- 普雷迪尼索隆,甲酸和德克萨米他酸被确定为混合物分析的主要贡献者.
结论:
- 少女早期的青春期与暴露于特定的合成类固醇激素,即halcinonide和budesonide有关.
- 合成类固醇激素的整体混合物和早熟的青春期之间没有发现显著的关联.
- 研究结果强调需要对合成类固醇激素进行环境监测和管理,以防止早发性.
更多相关视频
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
05:32Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
Published on: August 11, 2023
相关概念视频
Signs of Puberty
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Nature and Nurture
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...