在斑马鱼的早期生活中,暴露于老化聚烯微塑料会通过诱导线粒体功能障碍和氧化应激来影响亡
Ping Ding1, Chongdan Xiang2, Qian Yao3
1College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510630, China; State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, China.
Journal of environmental management
|July 31, 2024
概括
光衰老的微塑料 (MP) 对斑马鱼比原始的MP更有毒,通过氧化应激和线粒体亡引起发育问题. 需要进一步的研究,以了解和减轻老化MP对水生生态系统和人类健康的风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生态毒理学 生态毒理学
背景情况:
- 对水生生物的微塑料 (MP) 毒性越来越令人担忧.
- 在环境度下,老年MP的特定发育毒性和机制尚不清楚.
研究的目的:
- 在环境相关度下,对斑马鱼 (Danio rerio) 的原始聚钢 (P-PS) 和老化聚钢 (A-PS) 的发育毒性进行研究.
- 阐明毒性的潜在机制,包括氧化应激,线粒体功能障碍和亡.
主要方法:
- 斑马鱼幼虫暴露在P-PS和A-PS (0.1100μg/L) 中.
- 评估了发育终点 (死亡率,心率,身体长度,尾巴卷曲).
- 分析了氧化应激标记物 (ROS,DNA损伤),线粒体膜潜力 (MMP),细胞染色体c释放和基因表达.
主要成果:
- 在UV光衰老后,老化聚钢 (A-PS) 呈现出增加的结晶性和功能组.
- 与P-PS相比,A-PS暴露导致斑马鱼的发育毒性更大.
- A-PS诱导氧化损伤,DNA损伤,减少MMP和细胞染色体c释放,激活caspase-3/-9通路,暗示线粒体亡.
结论:
- 光衰老的微塑料对斑马鱼等水生生物构成重大发育风险.
- 氧化应激和线粒体亡是导致老年MP毒性的关键机制.
- 老年国会议员的环境风险需要进一步调查和对水生生态系统和人类健康的缓解策略.
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