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A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

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二类药物的电化学分类:一种综合的方法,结合了电压测量和液体染色学 - 质谱仪的见解

Jonas Schram¹, Marc Parrilla¹, Nick Sleegers¹

¹A-Sense Lab, Department of Bioscience Engineering, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium; NANOlab Center of Excellence, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium.

|July 31, 2024

概括

这项研究引入了一种新的电化学方法,用于识别假冒药片和饮料中的二氨酸 (BZs). 该技术将BZ分为三组,帮助执法部门和毒品检查部门在现场快速分析.

科学领域:

分析化学分析化学
电化学电化学电化学
法医科学法医科学法医科学

背景情况:

二类药物 (BZs) 的非医疗用途正在增加,导致假冒药物和新型精神活性物质 (NPS).
有效的分析方法对于执法部门,急救人员和药物检查服务至关重要,以便在各种样本类型中识别BZ,以便及时做出决定.

研究的目的:

在石墨印电极上研究亚泽帕姆,克洛纳泽帕姆和阿尔普拉佐拉姆的电化学行为.
根据其氧化还原信号和化学结构建立BZ的分类系统.
开发一种快速分析方法,用于识别被没收的药片和饮料中的BZ.

主要方法:

在不同氧气条件下使用石墨印电极对泽帕姆,克洛纳泽帕姆和阿尔普拉佐拉姆进行电化学分析.
液体染色学与高分辨率质谱学 (LC-HRMS) 结合,以阐明减少机制.
对22个没收的药丸和BZ的分析,这些药丸和BZ被添加到酒精饮料中,包括红酒.

主要成果:

根据它们的电化学行为和氧化还原中心,定义了三种不同的BZ结构类 (第1,2,3类).
脱氧条件显示了更高的选择性来分类BZs.
该方法成功地在没收的药片中识别了BZ,并检测到它们在加的酒精饮料中,在红葡萄酒分析中提出了双重pH的策略.

结论:

开发的电化学方法提供了BZ的快速,广泛的分析,稀释剂或颜料的干扰最小.
这种方法是各种服务打击有问题的BZ使用和促进现场药物识别的有希望的工具.

关键词:

这种药物是Benzodiazepines.在饮料中加.制造假冒制造假冒制造假冒电化学特征电化学特征电化学特征法医科学法医科学方形波电压测量方形波电压测量

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