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视觉化和响应pH的水凝抗菌涂层用于呼吸机相关的肺炎

Baokang Zhu¹, Hui Xin¹, Musheng Yang¹

¹Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China; Intensive Care Unit, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518031, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|July 31, 2024

概括

一种用于内管 (ETT) 的新型抗菌涂层可视化细菌感染,并释放药物以预防呼吸机相关肺炎 (VAP). 这种涂层在老鼠模型中表现出显著的抗生物膜和抗菌特性.

科学领域:

生物材料科学生物材料科学
传染性疾病传染性疾病
医疗器械涂层医疗器械涂层

背景情况:

呼吸机相关肺炎 (VAP) 是一种严重的医疗保健感染,与内管 (ETT) 上的细菌殖民有关.
现有的ETT为细菌生物膜形成提供了表面,使感染控制复杂化,特别是在长时间的通风场景中,如COVID-19所见的那样.

研究的目的:

为ETT开发一种pH响应的抗微生物涂层,既能表明感染,又能提供治疗剂.
在动物模型中评估这种涂层在防止生物膜形成和治疗VAP方面的有效性.

主要方法:

在基于PVC的ETT上制造了一种水凝涂层 (FK-MEM@CMCO-CS),使用奇托,碳氧甲基纤维素氧化 (CMCO),美罗 (MEM) 和FK13-a1.1.
涂层内含甲醇蓝 (BTB) 用于基于pH值的细菌活性视觉指示.
为了评估涂层性能,进行了体外和体内 (VAP大鼠模型) 研究.

主要成果:

在FK-MEM@CMCO-CS涂层中,MEM和FK13-a1.1的pH响应释放显示出MEM和FK13-a1.
观察到显著抑制细菌生物膜的形成和粘附.
在体内,该涂层减少了细菌生长,肺炎,并显示出良好的生物相容性.

结论:

开发的FK-MEM@CMCO-CS涂层是ETT的有效抗菌解决方案,能够发出感染信号和输送药物.
这项技术在防止VAP方面表现有前途,并有可能用于工业规模的生产.

关键词:

抗微生物涂层是一种抗微生物涂层.在VAP中使用VAP.视觉监控视觉监控视觉监控响应pH的反应性

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