经直流刺激改善了慢性精神分裂症的长期住院患者的晚期动力障碍
Xiaoli Lyu1, Zhe Li2, Siyu Chen3
1Yangzhou Wutaishan Hospital of Jiangsu Province, Teaching hospital of Yangzhou University, Yangzhou, China; Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China.
概括
经直流刺激 (tDCS) 在精神分裂症患者中显著改善了面部口腔运动症状. 这种安全的治疗为长期住院患有TD的患者提供了一个新的选择.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗器械 医疗器械
背景情况:
- 晚期动症 (TD) 是抗精神病药物的常见,往往不可逆转的副作用.
- 精神分裂症患者往往会经历显著的运动和社会障碍.
- 目前用于TD的治疗方法有效性有限,并且可能产生不良影响.
研究的目的:
- 评估跨直流刺激 (tDCS) 的疗效和安全性,用于治疗慢性住院精神分裂症患者的TD.
- 评估tDCS对运动症状的影响,用异常非自愿运动量表 (AIMS) 来衡量.
- 通过正负综合征量表 (PANSS) 和消极症状评估量表 (SANS) 检查tDCS对精神分裂症的正负症状的影响.
主要方法:
- 一项随机对照试验涉及64名长期住院的精神分裂症患者,他们被诊断为TD.
- 参与者接受了15次主动tDCS (强度为2mA,持续时间为30分钟) 或假装tDCS.
- 阳极被放置在左侧脊侧前额叶皮质上,阴极在右侧上轨道区域.
主要成果:
- 与假冒治疗相比,活性tDCS显著降低了AIMS总得分和面部-口腔子得分 (P<0.05).
- 活跃组的50%以上的患者在AIMS得分中显示出≥30%的改善,而假药组的8.3% (P<0.01).
- 两组之间在PANSS或SANS得分中没有发现显著差异;活跃组中感觉是报告的一种不良影响.
结论:
- tDCS在慢性住院精神分裂症患者改善TD的面部口腔运动症状方面表现出有效性和安全性.
- 这种神经调节技术为管理TD提供了一种新的治疗方法.
- 进一步的研究可能会探索优化tDCS参数以更广泛地改善TD的症状.
相关概念视频
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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