捐赠者-接受者匹配便微生物群移植在IBS-D患者中的有效性:一个单中心,随机,双盲,安慰剂控制的研究
Yanli Zhang1, Shuai Wang1, Huifen Wang1
1Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China.
Digestion
|July 31, 2024
概括
捐赠者与接受者匹配的便微生物群移植 (FMT) 显著改善了患有腹刺激性肠综合征 (IBS-D) 的患者的症状和生活质量. 这种个性化的方法也对肠道微生物群组成产生了积极的影响,与随机捐赠的FMT相比.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群失生症与刺激性肠道综合征 (IBS) 的发展和进展有关.
- 便微生物群移植 (FMT) 可以调节肠道微生物群.
- 捐赠者与接受者匹配的FMT提供了基于肠型的个性化方法.
研究的目的:
- 为了研究在IBS中与主要腹 (IBS-D) 匹配的捐赠者-接受者FMT的疗效.
- 评估匹配的FMT对IBS-D患者肠道微生物群组成的影响.
主要方法:
- 一项随机对照试验,涉及27名IBS-D患者.
- 提供者-接受者匹配的FMT (P组),随机捐赠者FMT (R组) 和安慰剂 (B组) 的比较.
- 评估症状得分 (IBS-SSS,IBS-QoL,GSRS) 和焦虑 (HADS) 在基线和4,8,12周治疗后,以及便样本分析.
主要成果:
- 组P在IBS-SSS,IBS-QoL,GSRS和焦虑评分 (p <0.05) 中显著改善.
- R组在IBS-QoL得分上表现出显著的改善 (p < 0.05).
- 贝塔多样性分析揭示了P组肠道微生物群组成的明显转变,其中七种细菌属与症状变化相关.
结论:
- 捐赠者-接受者匹配的FMT在改善IBS-D患者的临床症状,生活质量和焦虑方面比随机捐赠者FMT更有效.
- 个性化FMT在IBS-D中对肠道微生物群结构和功能产生重大影响.
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