在帕金森病中,双重任务性能和大脑形态特征在帕金森病中
Sarah J Carlson1, Yi-Fang Chiu2, Merrill R Landers3
1Department of Physical Therapy and Athletic Training, Saint Louis University, St. Louis, Missouri, USA, carlsonsj@slu.edu.
Neuro-degenerative diseases
|July 31, 2024
概括
帕金森病 (PD) 患者在双重任务 (DTs) 中表现更好的人在感觉运动区域的皮质较厚. 这些大脑差异突显了PD中自动性和双重任务的神经相关性.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 帕金森病 (PD) 损害了自动性,影响了双重任务 (DT) 性能和日常功能.
- 了解PD中DTs的神经基础对于开发向疗法至关重要.
- 这项研究调查了与PD患者的DT表现不同相关的大脑形态差异.
研究的目的:
- 探索患有帕金森病 (PD) 个体的大脑形态和双重任务 (DT) 性能之间的关系.
- 为了确定PD的低和高DT表现者之间的特定皮层和皮层下体积差异.
主要方法:
- 用体积核磁共振 (MRI) 来获得皮层厚度和皮层下体积,从34名患有PD的个人和47名健康的老年人中获得.
- 参与者被分为低或高的DT表现者,根据他们的表现在一个DT定时起动测试和连续减去任务.
- 统计分析包括非参数测试 (Quade的ANCOVA) 和等级线性回归,控制相关的共变量.
主要成果:
- 与DT表现较低的人相比,患有PD的个人在右侧主要体感皮质,双边主要运动皮质和双边补充运动区域中表现出较厚的皮质.
- 当一个健康的对照组被包括在内时,左侧原发皮层,左侧前额叶皮层和右侧补充运动区域的厚度也存在显著差异.
- 左侧中央叶片厚度是一个显著的预测因素,解释了20.8%的综合DT效应的变化.
结论:
- 在帕金森病 (PD) 中,双重任务 (DT) 的更高性能与明显的皮质形态特征有关,特别是在感觉运动区域.
- 这些发现表明,PD中增强的DT能力依赖于神经控制的融合,涉及传感运动集成,运动计划和运动激活.
- 这项研究确定了特定的大脑区域,这些区域可能是治疗干预的目标,旨在改善PD的自动性和双重任务.
更多相关视频
10:28Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
15.2K
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
7.8K
相关概念视频
01:15Parkinson's Disease: Overview
510
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
510
01:37Neural Regulation
39.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.2K
01:24Parkinson's Disease: Treatment
241
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
241