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Updated: Jun 18, 2025

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

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在Ret4响应元素的CRX/DNA识别和石基度的分子基础

Dhiraj Srivastava1, Pavithra Gowribidanur-Chinnaswamy1, Paras Gaur2

  • 1Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Structure (London, England : 1993)
|July 31, 2024
PubMed
概括

圆杆家庭盒 (CRX) 和神经视网膜白氨酸拉链 (NRL) 是视网膜转录的关键因素. 它们的结构相互作用和突变解释了光受体的发育和疾病机制.

关键词:
合作性是一种合作性.家庭 家庭领域 家庭领域光感受器的发展.视网膜疾病 视网膜疾病转录因子的转录因子

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CD Spectroscopy to Study DNA-Protein Interactions06:48

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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