一种人类共生病原菌通过向TBK1来抑制宿主免疫力
Gang Luo1, Jingkai Zhang1, Tianxu Wang1
1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China.
Cell host & microbe
|July 31, 2024
概括
虫 Candida albicans 通过注射一种能阻断 I 型干扰素信号传递的蛋白质来逃避免疫检测. 这种机制对于真菌殖民和感染至关重要,影响宿主免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- 虫是一种常见的人类殖民者,也是医院获得的真菌病的主要原因.
- 真菌的免疫逃避策略对于病变产生至关重要.
- I型干扰素 (IFN-I) 信号传输在宿主防御真菌感染方面发挥着关键作用.
研究的目的:
- 研究Candida albicans逃避宿主免疫反应的机制.
- 为了确定参与免疫调节的特定真菌效应蛋白.
- 了解IFN-I信号在C. albicans殖民和感染中的作用.
主要方法:
- 研究了真菌效应蛋白的转移到宿主细胞中的过程.
- 使用了一种cmi1突变菌株的C. albicans.
- 在小鼠感染模型和骨髓衍生的巨细胞中评估IFN-I反应.
- 分析了Cmi1对TANK结合激酶1 (TBK1) 和IFN调节因子3 (IRF3) 酸化的影响.
- 研究了IFN-I受体在宿主反应中的作用.
主要成果:
- C. albicans将效应蛋白Cmi1转移到宿主细胞中,以阻止IFN-I信号传递.
- Cmi1抑制TBK1,防止IRF3酸化,并抑制IFN-I级联.
- 感染cmi1突变的小鼠表现出增强的IFN-I反应,导致更快的真菌清除和更高的生存率.
- 损失CMI1损害了肠道共生,并增加了结肠细胞中的IFN-I反应,因IFN-I受体枯竭而扭转效应.
结论:
- 效应蛋白Cmi1通过抑制TBK1-介导的IFN-I信号传递,对C. albicans的免疫逃避至关重要.
- 抑制TBK1是C. albicans的关键毒性机制.
- C. albicans通过效应蛋白传递操纵宿主免疫力,影响感染和开始殖民.
更多相关视频
相关概念视频
01:29Pulmonary Tuberculosis I
228
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
228
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:28Pulmonary Tuberculosis II
215
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
215
01:40Cell-mediated Immune Responses
68.0K
Overview
68.0K
02:26NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
01:28Cells of the Innate Immune Response
1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K