在25至95岁的没有糖尿病和糖尿病的德国人中,功能和功能下降的基于人口的参考值
Janina M Herold1, Simon Wiegrebe2, Jana Nano3
1Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Kidney international
|July 31, 2024
概括
正常的功能衰老是慢性病风险的关键. 这项研究为估计的淋巴细胞过率 (eGFR) 和其下降提供了特定年龄的参考值,有助于临床评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 了解正常的衰老对于识别慢性病 (CKD) 风险至关重要.
- 使用血清肌素 (eGFRcrea) 或囊素C (eGFRcys) 估计的淋巴球过率 (eGFR) 是常见的措施.
- 基于人口的eGFR参考值和其在广泛的年龄范围内的下降是有限的.
研究的目的:
- 为了建立特定年龄组的eGFRcrea和eGFRcys.的参考值.
- 为了确定每年eGFR下降的基于人口的参考值.
- 帮助临床医生解释eGFR值,并根据年龄和风险因素预测eGFR下降.
主要方法:
- 来自德国四个基于人口的队列 (KORA-3, KORA-4, AugUR, DIACORE) 的横截面和纵向数据的分析.
- 包括大约12,000名25-95岁的个人,在25年内多达5次测量.
- 使用线性混合模型对eGFRcrea和eGFRcys进行纵向分析.
主要成果:
- 在截面上,eGFRcrea随着年龄的增长线性下降;eGFRcys下降到60岁.
- 一般人群的年度eGFRcrea下降估计为-0.80mL/min/1.73m2,"健康"个体为-0.79,糖尿病患者为-1.20.
- 为各种子组提供了eGFR和eGFR下降的参考值和预测间隔.
结论:
- 该研究提供了关于eGFR和eGFR下降的重要年龄特定参考数据.
- 这些发现有助于临床医生评估功能,并识别患有慢性病风险较高的人.
- 建立的参考值可以用来比较个别的eGFR与人口规范和预期的衰老轨迹.
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