基于AOP的框架,用于预测二--2-乙烯基甲酸盐和双甲联合暴露对自闭症谱系障碍的联合作用模式
Kanglong Cui1, Ludi Li1, Kai Li1
1Department of Toxicology, School of Public Health, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China.
Neurotoxicology
|July 31, 2024
概括
环境污染物二二甲基甲酸盐 (DEHP) 和双A (BPA) 可能会增加自闭症风险. 这项研究表明,它们的联合作用是附加的或协同的,影响神经发育途径.
科学领域:
- 环境毒理学环境毒理学
- 神经发育障碍 神经发育障碍
- 计算生物学是一种计算生物学.
背景情况:
- 自闭症谱系障碍 (ASD) 的患病率正在上升,与环境因素有关.
- 对DEHP和BPA等内分泌干扰物的暴露与ASD风险增加有关.
- 在ASD发展中DEHP和BPA的联合行动机制仍然不清楚.
研究的目的:
- 阐明DEHP和BPA共同暴露在ASD发展中的联合作用模式.
- 为DEHP/BPA相关的ASD构建和分析化学-基因-表型-疾病网络 (CGPDN).
- 确定潜在的不良结果途径 (AOPs),将这些暴露与ASD联系起来.
主要方法:
- 使用了不利结果路径 (AOP) 框架.
- 从公共数据库中整合数据,为DEHP和BPA相关的ASD建立CGPDNs.
- 进行拓分析和文献探索,以构建AOPs.
主要成果:
- 确定了两种与ASD相关的潜在AOP:降低N-甲基-D-酸盐受体 (NMDAR) 和雌激素对抗性.
- 分析表明,DEHP和BPA的同时暴露可能具有添加性或协同作用.
- 在构建的网络中发现了共享的关键事件和现象.
结论:
- 同时暴露于BPA和DEHP可能会增加或协同增加ASD的风险.
- 已识别的AOP为了解分子机制提供了一个框架.
- 需要进一步的研究来确认拟议的联合行动模式.
关键词:
在 AOP AOP 中.在ASD中,使用的是ASD.BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA共同暴露 共同暴露在DEHP中,DEHP是DEHP.联合行动模式 联合行动模式更多相关视频
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