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Updated: Jun 18, 2025

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
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In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

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针对Trypanosoma cruzi蛋白酶体的新型抑制剂的结构分析和基于形状的识别

Guilherme Martins Silva1, Suzane Quintana Gomes2, Carla Duque Lopes3

  • 1Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Computational Laboratory of Pharmaceutical Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, Ribeirão Preto, SP 14040-903, Brazil.

International journal of biological macromolecules
|July 31, 2024
PubMed
概括

研究人员确定了包括LCQFTC11在内的新型化合物,这些化合物显示出抑制Trypanosoma cruzi蛋白酶体的潜力. 这为开发对查加斯病 (CD) 更安全的药物提供了有希望的新途径.

关键词:
查加斯病是查加斯病的一种疾病.停靠的对接方式在MMGBSA中,我们可以看到MMGBSA.分子动力学分子动力学蛋白质酶体是一种蛋白质酶体.基于形状的相似性基于形状的相似性.虚拟选是一个虚拟的选.

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