医院治疗的传染病,感染负担和肺癌风险:观察性和门德尔随机化研究
Jiazhen Zheng1, Jinghan Huang2, Quan Yang3
1Bioscience and Biomedical Engineering Thrust (J. Z. and S.T.), Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, China.
感染,特别是下呼吸道感染 (LRTI),显著增加肺癌的风险. 这种关联得到了观察和遗传证据的支持,突出显示感染是肺癌发展的关键因素.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 感染在肺癌发展中的作用受到争论.
- 关于影响肺癌风险的特定病原体类型和感染部位的数据有限.
研究的目的:
- 调查感染与肺癌风险之间的纵向关联.
- 为了确定特定的微生物或整体感染负担是否会影响肺癌风险.
主要方法:
- 利用英国生物库的数据,研究了900多种传染病.
- 采用时间变化的考克斯模型和门德尔随机化用于因果推理.
- 评估感染负担,并按病原体类型和感染地点分层.
主要成果:
- 在医院治疗的感染与肺癌风险增加有关 (aHR, 1.79).
- 下呼吸道感染 (LRTI) 显示出最强的关联 (aHR,3.22).
- 在感染负担和肺癌风险之间发现了剂量反应关系.
结论:
- 观察和遗传数据都证实传染病增加了肺癌风险.
- 了解LRTIs和其他感染的影响可以为预防策略提供信息.
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