阿尔茨海默病连续体中的结构性大脑差异:从大型多站点神经成像联盟对异质性的洞察
Tavia E Evans1, Natalia Vilor-Tejedor2, Gregory Operto3
1Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
概括
使用神经成像数据进行的全球阿尔茨海默氏病 (AD) 研究显示,虽然不同数据集的模式相似,但种族群体表现出初步差异. 协调处理和透明度对于未来的合作研究至关重要.
科学领域:
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
- 多站点研究 多站点研究
背景情况:
- 神经退行性疾病需要协作,多站点的研究.
- 数据异质性给全球数据聚合带来了挑战.
- 在阿尔茨海默病 (AD) 阶段和异质性来源中研究大脑结构.
研究的目的:
- 为了研究跨AD阶段的大脑结构.
- 了解神经成像标志物-AD关系在数据异质性之间如何变化.
- 评估数据采集,研究设计和人群对研究结果的影响.
主要方法:
- 使用了6个国际数据集 (N > 27,000).
- 对结构神经成像标记物进行了元分析,与AD连续性相关.
- 检查了磁共振成像采集,研究设计和种群之间的关联的变化.
主要成果:
- 根据数据采集方法,观察到关联的适度差异,但整体模式仍然相似.
- 初步发现表明,神经成像标志物-AD关系在各族群之间存在差异.
- 分析显示,尽管数据异质,但仍存在一致的模式.
结论:
- 数据多样性为AD的神经基础提供了宝贵的见解.
- 统一的数据处理和透明的数据收集对于全球合作至关重要.
- 未来的研究应该在元分析阶段接受和量化数据异质性.
更多相关视频
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
17.3K
12:50Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
40.2K
相关概念视频
01:26Alzheimer's Disease: Overview
456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456
01:14Brain Imaging
219
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
219